Opportunity
A leading biotech company, an innovative biotech company in the skincare industry, faced critical challenges in optimizing the delivery of active compounds through the skin for their hyperpigmentation treatments and UV protection products. The efficacy of skincare formulations heavily depends on the successful permeation of active ingredients through the stratum corneum - a fundamental challenge in dermatological science. Traditional approaches relied on time-consuming trial-and-error experimentation, significantly slowing product development cycles and increasing costs.
Challenge
- Compound Permeation Prediction: Accurately forecasting how various compounds penetrate the skin with and without enhancers.
- Optimal Formulation Identification: Determining effective combinations of active compounds and penetration enhancers (PEs).
- Macro-Molecule Delivery: Facilitating the permeation of larger molecules, such as peptides, through the highly selective skin barrier.
- Efficacy vs. Tolerability Balance: Maximizing compound delivery while minimizing skin irritation and maintaining product safety.
Solution
1D.works partnered with the client to develop the Skin Permeation Platform, a comprehensive data-driven solution:
- Comprehensive Data Foundation: Created a structured database of compound-PE combinations by extracting and standardizing permeation data from extensive scientific literature.
- Automated Data Acquisition: Developed specialized scrapers for PubMed and Google Scholar to systematically collect relevant research findings.
- Standardized Analysis Framework: Implemented consistent methodologies for comparing permeation data across different experimental models and measurement units.
- Trend Identification: Applied advanced analytics to identify high-potential compound-PE combinations and correlations between molecular properties and permeation success.
Clear ROI and Results
- Accelerated Research: Reduced formulation development time by providing instant access to permeation data that would otherwise require extensive literature reviews.
- Evidence-Based Decision Making: Enabled formulation decisions based on comprehensive data rather than limited experimental trials.
- Novel Combination Discovery: Identified previously overlooked compound-PE combinations with superior permeation characteristics.
- Development Cost Reduction: Decreased the number of required experimental trials by pre-screening formulations using historical permeation data.
By transforming scattered scientific knowledge into structured, actionable insights, the Suneco Permeation Platform established a solid foundation for data-driven skincare innovation, positioning Sūneco Technologies at the forefront of scientific skincare development.