Opportunity
A biotech company in the skincare industry wanted a more structured way to investigate the delivery of active compounds through the skin for hyperpigmentation and UV-protection products. The team needed to compare scattered research about compounds, penetration enhancers, experimental models, and measurement units.
Challenge
- Compound Permeation Prediction: Accurately forecasting how various compounds penetrate the skin with and without enhancers.
- Optimal Formulation Identification: Determining effective combinations of active compounds and penetration enhancers (PEs).
- Macro-Molecule Delivery: Facilitating the permeation of larger molecules, such as peptides, through the highly selective skin barrier.
- Efficacy vs. Tolerability Balance: Maximizing compound delivery while minimizing skin irritation and maintaining product safety.
Solution
1D.works partnered with the client to develop the Skin Permeation Platform, a comprehensive data-driven solution:
- Comprehensive Data Foundation: Created a structured database of compound-PE combinations by extracting and standardizing permeation data from extensive scientific literature.
- Automated Data Acquisition: Developed specialized scrapers for PubMed and Google Scholar to systematically collect relevant research findings.
- Standardized Analysis Framework: Implemented consistent methodologies for comparing permeation data across different experimental models and measurement units.
- Trend Identification: Applied advanced analytics to identify high-potential compound-PE combinations and correlations between molecular properties and permeation success.
Delivered Capabilities
- Structured Research Access: Brought extracted permeation data into a searchable, standardised dataset.
- Comparable Evidence: Helped researchers compare results across different experimental models and measurement units.
- Candidate Screening: Surfaced compound and penetration-enhancer combinations for further expert review and experimental validation.
- Research Prioritisation: Supported decisions about which hypotheses to examine next without claiming to replace laboratory trials.
The Sūneco Permeation Platform transformed scattered literature into a structured research resource. Effects on formulation performance, trial counts, development time, or cost require validation by the client.
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